Dose ranges reflect commonly studied amounts in published research models. This is not medical advice. For research use only. Not for human consumption.
Protocol Comparison
Cognitive
Research dose range
Standard research range
600 - 900 mcg
The range three decades of Russian research keeps landing on — the sweet spot, not a guess.
Research focus
Cognitive enhancement / neuroprotection
Observed window
BDNF effect peaks 3-8 hrs, sustained ~24 hrs
Administration
When needed
Primary pathway
BDNF / NGF / MC3R / MC4R (partial) / Enkephalin
Dosing carried over from intranasal research protocols and Russian clinical literature — no SC-specific human dosing data currently exists. For research use only.
PROTOCOL BENEFITS
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Drives a fast, measurable rise in BDNF and NGF in the hippocampus and prefrontal cortex — the neurotrophic signal behind memory formation and neuroplasticity.
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Carries the cognitive and neuroprotective properties of ACTH without the cortisol spike — engineered to strip out the adrenal-stimulating activity of its parent hormone.
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Backed by three decades of clinical use in Russia for stroke recovery and cognitive impairment — one of the more clinically established peptides in this category.
SCIENCE
Semax is built from the ACTH(4-10) fragment, with an added Pro-Gly-Pro tail that changes everything about how it behaves. The natural fragment gets broken down by peptidases within seconds; Semax's tail lets it survive long enough to actually do its job — driving a measurable rise in BDNF and NGF gene expression within hours of dosing.
The stroke-recovery story runs deep — Semax has been a registered Russian medicine for ischemic stroke and cognitive disorders since the 1990s, with three decades of institutional clinical use behind it. That track record is real, but it's also almost entirely Russian: Western regulators haven't reviewed it, and independent replication outside Russia remains limited.
WHAT TO EXPECT
Subjective focus effects have been reported within 20-40 minutes in research protocols, peaking around 1-2 hours. The underlying BDNF effect builds over hours and stays elevated for up to 24 hours per dose.
PROTOCOL NOTE
Available in 5mg. For research use only. Full documentation included with every order.
FAQ
Semax doesn't work through acute neurotransmitter release the way stimulants do — its effects build over days to weeks through neurotrophic and neuroplasticity mechanisms instead.
It's been a registered prescription medicine in Russia since the 1990s for stroke recovery and cognitive disorders — a longer track record than most compounds in this category, though almost entirely Russian.
