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Synthetic fragment of Thymosin Beta-4 retaining active actin-sequestration signaling.
Dose ranges reflect commonly studied amounts in published research models. This is not medical advice. For research use only. Not for human consumption.
Protocol Comparison
Research Dose Reference
Available in 5 mg
TB-500
Recovery
Research dose range
0 mg1.25 mg2.5 mg3.75 mg5 mg
Standard research range
2 - 4 mg
Standard research protocol for acute muscle, tendon, ligament, or soft-tissue injury models.
Research focus
Systemic tissue repair, cell motility & angiogenesis
Observed window
4-8 weeks
Administration
Twice weekly laboratory protocol
Primary pathway
G-actin sequestration / VEGF / ILK/Akt signaling
Mechanism reference: Grant et al., Angiogenesis, 1999. Dosing synthesized from experimental tissue repair literature. For laboratory research only.
PROTOCOL BENEFITS
Engineered Outcomes
Actin SequestrationSystemic Tissue RepairAngiogenesis Signaling
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Promotes G-actin binding to facilitate rapid cell migration toward damaged tissue sites.
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Upregulates VEGF signaling for new capillary angiogenesis and supports ILK/Akt cell survival pathways.
SCIENCE
How It Works.
TB-500 is a synthetic peptide containing the central active fragment (LKKTET) of Thymosin Beta-4, a major intracellular actin-sequestering protein. Unlike BPC-157 which primarily provides localized repair signaling, TB-500 exerts broad systemic effects on cell motility.
By binding G-actin and preventing its premature polymerization into filaments, TB-500 maintains cells in an active mobile state, accelerating the recruitment of repair precursors, fibroblasts, and endothelial cells directly into injured tissues.
WHAT TO EXPECT
Systemic recovery signaling builds progressively through cell migration and angiogenesis cascades. Research models evaluate tissue remodeling and functional recovery over 4–8 weeks.
PROTOCOL NOTE
Available in 5 mg sterile vials. For laboratory research use only.
FAQ
Protocol Questions
What is the difference between TB-500 and BPC-157?+
BPC-157 is primarily studied for focal, localized tissue repair signaling at the site of trauma. TB-500 is associated with systemic recovery through G-actin sequestration, maintaining cell motility and accelerating precursor cell migration across tissues.
Why does TB-500 use a peptide fragment rather than the full-length protein?+
The LKKTET hexapeptide is the active actin-binding epitope responsible for cellular migration signaling, offering superior stability and targeted research focus compared to the whole 43-amino-acid Thymosin Beta-4 protein.
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